2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129889
    Febuxostat acyl glucuronide
    Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor.
    Febuxostat acyl glucuronide
  • HY-110034
    Didesmethylsibutramine hydrochloride
    Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis.
    Didesmethylsibutramine hydrochloride
  • HY-N12462S
    Glycochenodeoxycholic acid 3-sulfate-d4
    Glycochenodeoxycholic acid 3-sulfate-d4 (GCDCA-S-d4) is the deuterium labeled Glycochenodeoxycholic acid 3-sulfate (HY-N12462). Glycochenodeoxycholic acid 3-sulfate (GCDCA-S; 3-Sulfate-GCDCA) is a. Glycochenodeoxycholic acid 3-sulfate can serve as hepatocellular carcinoma biomarker.
    Glycochenodeoxycholic acid 3-sulfate-d<sub>4</sub>
  • HY-179367
    AR-102 free acid
    AR-102 free acid, an active metabolite of AR-102 (HY-19885), is a prostaglandin F (PGF) derivative.
    AR-102 free acid
  • HY-A0111B
    Cefetamet hydrochloride
    Cefetamet (Ro 15-8074) hydrochloride is a cephalosporin antibiotic and the active metabolite of Cefetamet pivoxil (HY-B1894A). Cefetamet hydrochloride binds to bacterial penicillin-binding protein (PBP) (IC50 for PBP3 in Escherichia coli W3110 is 2.5 μg/mL). Cefetamet hydrochloride has significant activity against Gram-negative bacteria such as Enterobacteriaceae, Neisseria species, and Haemophilus influenzae, as well as Gram-positive bacteria such as Streptococcus. Cefetamet hydrochloride kills and lyses Treponema pallidum. Cefetamet hydrochloride can be used in the research of respiratory tract, urinary tract, ear, nose and throat infections, and syphilis.
    Cefetamet hydrochloride
  • HY-113442
    6-trans-12-epi-Leukotriene B4
    6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.
    6-trans-12-epi-Leukotriene B4
  • HY-W008449S2
    1-Methylxanthine-d3
    1-Methylxanthine-d3 is deuterated labeled 1-Methylxanthine (HY-W008449). 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells.
    1-Methylxanthine-d<sub>3</sub>
  • HY-135381
    3-Oxo Atorvastatin
    3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
    3-Oxo Atorvastatin
  • HY-113269R
    alpha-CEHC (Standard)
    Sulfacetamide (sodium monohydrate) (Standard) is the analytical standard of Sulfacetamide (sodium monohydrate). This product is intended for research and analytical applications. 0
    alpha-CEHC (Standard)
  • HY-W019773S1
    Albendazole sulfone-d3
    Albendazole sulfone-d3 is the deuterium labeled Albendazole sulfone. Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone-d<sub>3</sub>
  • HY-116617R
    15-Keto Travoprost (Standard)
    Cefotaxime (Standard) is the analytical standard of Cefotaxime. This product is intended for research and analytical applications. Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
    15-Keto Travoprost (Standard)
  • HY-138094
    N-(2-Hydroxyethyl)oxamic acid
    N-(2-hydroxyethyl)-oxamic acid is formed when Metronidazole is reduced either chemically or by the action of the intestinal bacteria. Metronidazole, a nitroimidazole antibiotic, has activity against various protozoans and most Gram-negative and Gram-positive anaerobic bacteria.
    N-(2-Hydroxyethyl)oxamic acid
  • HY-137316AR
    Phosphoramide mustard cyclohexanamine (Standard)
    Phosphoramide mustard (cyclohexanamine) (Standard) is the analytical standard of Phosphoramide mustard (cyclohexanamine). This product is intended for research and analytical applications. Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage[1][2].
    Phosphoramide mustard cyclohexanamine (Standard)
  • HY-148376
    Abiraterone N-oxide
    Abiraterone N-oxide is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity.
    Abiraterone N-oxide
  • HY-12770R
    Mebeverine alcohol (Standard)
    Mebeverine alcohol (Standard) is an analytical standard for Mebeverine alcohol. This product is intended for research and analytical applications. Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of Chloramphenicol (HY-B0239) and Lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis.
    Mebeverine alcohol (Standard)
  • HY-117580R
    16α-Hydroxyprednisolone (Standard)
    16α-Hydroxyprednisolone (OH-PRED) (Standard) is the analytical standard of 16α-Hydroxyprednisolone. This product is intended for research and analytical applications. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily.
    16α-Hydroxyprednisolone (Standard)
  • HY-145949
    Remdesivir de(ethylbutyl 2-aminopropanoate)
    Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
    Remdesivir de(ethylbutyl 2-aminopropanoate)
  • HY-161487
    AOZ/BSA
    AOZ/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    AOZ/BSA
  • HY-W403046A
    D-myo-Inositol-4-phosphate monoammonium
    D-myo-Inositol-4-phosphate monoammonium is a metabolite of D-myo-Inositol 1,4,5-trisphosphate. D-myo-Inositol 1,4,5-trisphosphate, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2) .
    D-myo-Inositol-4-phosphate monoammonium
  • HY-116546
    Sch 40853
    Sch 40853 is a active metabolite of SCH 39166 (HY-14690) and can be used for the research of schizophrenia and obesity.
    Sch 40853
Cat. No. Product Name / Synonyms Application Reactivity